Research

My ICU

Research is an integral component of the Intensive Care Unit at Barwon Health. It ensures we continually understand how best to treat patients and adapt to changes in health science. Conducting research in the critically ill requires particular skills, experience and sensitivity. Our dedicated and experienced ICU research nurses are a pivotal interface between clinicians, patients, families, coordinating centres and hospital research governance processes. Our fortnightly research meeting allows ICU staff to be updated on the progress of all research projects and consider proposals for new studies. This forum is an effective means of engaging clinical staff and identifying appropriate future studies and collaborations. During 2018 / 2019, there were 1,735 patients admitted to ICU. Overall there were 2,688 episodes of screening, and 134 ICU patients (7.7%) participated in clinical research. This is higher than last year (4.5%), and higher than the rate reported in Australia / New Zealand (approx. 2%). For further information go to; www.barwonhealth.org.au, click on Research, click on Research Ethics, Governance and Integrity Unit.
UHG ICU Research Staff

Head of Research

Research Co-ordinators

  • Allison Bone
  • Tania Salerno

Clinical Researchers

Publications

2020

  • Simpson NB, Shankar-Hari M, Rowan KM etal. Maternal Risk  Modelling in Critical Care - Development of a Mulitvariable Risk Prediction Model for Death an Prolonged Intensive Care. Crit Care Med. 2020 Mar 13. 
  • Maiden MJ, Cmeron PA, Rosenfeld JV, et al. Long-term Outcomes after Severe Traumatic Brain Injury in Older Adults. A REgistry-based Cohort Study. Am J Resp Crit Care Med. 2020 Jan 15;201(2):167-177.
  • Thurston LM, Milnes SL, Hodgson CL, Berkovic DE, Ayton DR, Iwashyna TJ, Orford NR. Defining patient-centred recovery after critical illness – A qualitative study. J Crit Care. 2020 Feb 6;57:84-90.
  • Fuji T, Luethi N, Young P, ..

    Orford NR

    , et al for the VITAMINS Trial Investigators. Vitamin C, Hydrocortisone, and Thiamine in Patients with Septic Shock: The VITAMINS Randomized Clinical Trial. JAMA. 2020 Jan 17.

  •  

    Ragg M, Ragg J, Milnes S, Bailey M, Orford N. Patients with life-limiting illness presenting to the emergency department. Emerg Med Australas. 2020 Apr;(32(2):288-294.

2019

  • Maiden MJ, Torpy DJ. Thyroid hormones in critical Illness. Crit Care Clin. 2019 Apr;35(2):375-388.
  • McCaffrey J, Maiden MJ, Norrish C. In-hospital cardiac arrests: events worth monitoring? Crit Care Resusc. 2018 Dec;20(4):320.
  • Duke GJ, Maiden MJ, Huning EYS, et al. Severe acute maternal morbidity trends in Victoria, 2001-2017. Aust NZJ Obstet Gynaecil. 2019 Dec 1.
  • Milnes S, Orford NR, Berkeley L, Lambert N, Simpson N, Elderkin T, Corke C, Bailey M. A prospective observational study of prevalence and outcomes of patients with Gold Standard Framework criteria in a tertiary regional Australian hospital. BMJ Support Palliat Care. 2019 Mar;9(1):92-99.
  • Dunn MS, Beck B, Simpson PM, Cameron PA, Kennedy M, Maiden M, Judson R, Gabbe BJ. Comparing the outcomes of isolated, serious traumatic brain injury in older adults managed at major trauma centres and neurosurgical services: A registry-based cohort study. Injury. 2019 Jun 10. pii: S0020-1383(19)30352-3.
  • Orford NR, Milnes S, Simpson N, Keely G, Elderkin T, Bone A, Martin P, Bellomo R, Bailey M, Corke C. Effect of communication skills training on outcomes in critically ill patients with life-limiting illness referred for intensive care management: a before-and-after study. BMJ Support Palliat Care. 2019 Mar;9(1):e21.
  • Orford NR, Pasco JA, Kotowicz MA. Osteoporosis and the critically ill patient. Crit Care Clin. 2019 Apr;35(2):301-313.
  • Simpson N, Milnes S, Martin P, Phillips A, Silverman J, Keely G, Forrester M, Dunning T, Corke C, Orford N. iValidate: a communication-based clinical intervention in life-limiting illness. BMJ Support Palliat Care. 2019 Apr 11.
  • Livingston A, Brooks L, Orford N, Lamb-Jenkins J, Hutchinson A. Excessive Supplemental Oxygen Delivery to Mechanically Ventilated Patients is Based on Unit Culture. Australian Critical Care. 2019;32:S9.
  • Vitamin C, Hydrocortisone and Thiamine in Patients with Septic Shock (VITAMINS) trial: study protocol and statistical analysis plan. Fujii T, Udy AA, Deane AM, Luethi N, Bailey M, Eastwood GM, Frei D, French C, Orford N, Shehabi Y, Young PJ, Bellomo R; VITAMINS trial investigators. Crit Care Resusc. 2019 Jun;21(2):119-125

2018

  • Eyeington CT, Glassford NJ, Darvall J ..Simpson N, etal.Ventilation management in Victorian intensive care unit patients without acute respiratory distress syndrome. Crit Care Resusc. 2018 Jun;20(2):101–8.
  • Orford N. Grief After Suicide. JAMA. 2018;320(18):1861-1862.
  • Orford NR, Bailey M, Bellomo R, Pasco JA, Cooper DJ, Kotowicz MA. Changes in bone mineral density in women before critical illness: a matched control nested cohort study. Arch Osteopor. 2018 Nov 5;13(1):119.
  • Poole AP, Anstey J, Bellomo R... Maiden MJ, etal. Opinions and practices of blood glucose control in critically ill patients with pre-existing type 2 diabetes in Australian and New Zealand intensive care units. Aust Crit Care. 2018 Oct 19. pii: S1036-7314(18)30129-2.
  • Reddi B, Finnis M, Udy AA, Maiden M, etal for the; ARISE Study Management Committee and the ANZICS CTG. The relationship between the change in central venous pressure and intravenous fluid volume in patients presenting to the emergency department with septic shock. Intensive Care Med. 2018 Sep;44(9):1591-1592.
  • Tipping CJ, Holland AE, Harrold M, Crawford T, Halliburton N, Hodgson CL. The minimal important difference of the ICU mobility scale. Heart Lung. 2018 Sep - Oct;47(5):497-501.

2017

  • Orford NR, Bailey M, Bellomo R, Pasco JA, Cattigan C, Elderkin T, Brennan-Olsen S, Kotowicz M. The association of time and medications with changes in bone mineral density in the 2 years after critical illness. Crit Care. 2017;21(1):69. doi:10.1186/s13054-017-1657-6.
  • Milnes S, Corke C, Orford NR, Bailey M, Savulescu J, Wilkinson D. Patient values informing medical treatment: a pilot community and advance care planning survey. BMJ Supportive & Palliative Care. March 2017:bmjspcare–2016–001177. doi:10.1136/bmjspcare-2016-001177 

2016

  • McCaffrey J, Orford NR, Simpson N, Jenkins JL, Morley C, Pellegrino V. Service delivery model of extracorporeal membrane oxygenation in an Australian regional hospital. Crit Care Resusc. 2016;18(4):35-241

  • Gabriel L, Bailey M, Bellomo R, Stow P, Orford N, et al. Insurance status and mortality in critically ill patients. Crit Care Resusc. 2016;18(1):43-9.

  • Maiden MJ, Chapman MJ, Torpy DJ, Kuchel TR, Clarke IJ, Nash CH, Fraser JD, Ludbrook GL. Triiodothyronine Administration in a Model of Septic Shock: A Randomized Blinded Placebo-Controlled Trial. Crit Care Med. 2016 Epub.

  • Maiden MJ, Otto S, Brealey JK, Finnis ME, Chapman MJ, Kuchel TR, Nash CH, Edwards J, Bellomo R. Structure and Function of the Kidney in Septic Shock: A Prospective Controlled Experimental Study. Am J Respir Crit Care Med. 2016 Epub

  • Orford N, Milnes S, Lambert N, Berkeley L, Lane S, Simpson N, Elderkin T, Bone A, Martin P, Corke C, Bellomo R, Bailey M. Prevalence, goals of care discussions, and long-term outcomes of patients with life-limiting illness referred to intensive care. Crit Care Resusc. Accepted for publication Mar 2016

  • Orford NR, Lane SE, Bailey M, et al. Changes in Bone Mineral Density in the Year After Critical Illness. Am J Respir Crit Care Med. November 2015:rccm.201508–1514OC.

  • Dixon B, Smith R, Santamaria JD, Orford NR, Wakefield BJ, Ives K, McKenzie R, Zhang B, Yap CH. A trial of neubulised heparin to limit lung injury following cardiac surgery. Anaesth Intensive Care 2016;44(1):28-33  

  • Verma B, Luethi N, Cioccari I, Lloyd-Donald P, Crisman M, Orford NR, French C, Bellomo R, Martensson J. A multicentre randomised controlled pilot study of fluid resuscitation with saline or Plasma-Lyte 148 in critically ill patients. Crit Care Resusc 2016;18(3): 205-12

  • Tai A , Corke C, Joynt GM, Griffith J, Lunn, D, Tong P. A comparative study of tracheal diameter in Caucasian and Chinese patients. Anaesth Intensive Care. 2016 Nov;44(6)719-723.

  • Venkatesh B , Corke C, Raper R, Pinder M, Stephens D, Joynt G, Morley P, Bellomo R, Bevan R, Freebairn R, Varghese B, Ashbolt M, Hawker F, Jacobe S, Yong S. Prevalence of bullying, discrimination and sexual harassment among trainees and Fellows of the College of Intensive Care Medicine of Australia and New Zealand. Crit Care Resusc. 2016 Dec;18(4)230-234.

  • Venkatesh B , Corke C, Raper R, Pinder M, Stephens D, Joynt G, Morley P, Bellomo R, Bevan R, Freebairn R, Varghese B, Ashbolt M, Hawker F, Jacobe S, Yong S. Findings of the bullying, discrimination and sexual harassment survey: response of the College of Intensive Care Medicine. Crit Care Resusc. 2016 Dec;18(4)228-229.

2015

  • Milnes S, Orford NR,  Berkeley L, Lambert N, Simpson N, Elderkin T, Corke C, Bailey M.  A prospective observational study of prevalence and outcomes of patients with Gold Standard Framework criteria in a tertiary regional Australian Hospital.  BMJSPCare. 2015. Epub

  • Entesari-Tatafi D, Orford N, Bailey MJ, Chonghaile MN, Lamb-Jenkins J, Athan E.  Effectiveness of a care bundle to reduce central line-associated bloodstream infections.  Med J Aust 2015 Mar;202(5):247-250.

  • Henderson W, Corke C. The utility of a Personal Values Report for medical decision-making. Anaesth Intensive Care. 2015 Sep;43(4):608-611.

  • Dulhunty JM, Roberts JA, Davis JS, Webb SA, Bellomo R, Gomersall C, Shirwadkar C, Eastwood GM, Myburgh J, Paterson DL, Starr T, Paul SK, Lipman J; BLING II Investigators for the ANZICS Clinical Trials Group. A Multicenter Randomized Trial of Continuous versus Intermittent beta-Lactam Infusion in Severe Sepsis. Am J Respir Crit Care Med. 2015 Dec;192(11):1298-1305.

  • Santamaria JD, Duke GJ, Pilcher DV, Cooper DJ, Moran J, Bellomo R; Discharge and Readmission Evaluation (DARE) Study. he timing of discharge from the intensive care unit and subsequent mortality. A prospective, multicenter study. Am J Respir Crit Care Med. 2015 May;191(9):1033-1039.

  • Reddy SK, Young PJ, Beasley RW, Mackle DM, McGuinness SP, McArthur CJ, Henderson SJ, Weinberg L, French CJ, Orford NR, Bailey MJ, Bellomo R. Overview of the study protocols and statistical analysis plan for the Saline versus Plasma-Lyte 148 for Intravenous Fluid Therapy (SPLIT) research program. Crit Care Resusc. 2015 Mar;17(1):29-36.

  • Lim W, Meade M, Lauzier F, Zarychanski R, Mehta S, Lamontagne F, Dodek P, McIntyre L, Hall R, Heels-Ansdell D, Fowler R, Pai M, Guyatt G, Crowther MA, Warkentin TE, Devereaux PJ, Walter SD, Muscedere J, Herridge M, Turgeon AF, Geerts W, Finfer S, Jacka M, Berwanger O, Ostermann M, Qushmaq I, Friedrich JO, Cook DJ; PROphylaxis for ThromboEmbolism in Critical Care Trial Investigators. Failure of anticoagulant thromboprophylaxis: risk factors in medical-surgical critically ill patients*. Crit Care Med. 2015 Feb;43(2):401-410.

  • Hodgson C, Bellomo R, Berney S, Bailey M, Buhr H, Denehy L, Harrold M, Higgins A, Presneill J, Saxena M, Skinner E, Young P, Webb S. Early mobilization and recovery in mechanically ventilated patients in the ICU: a bi-national, multi-centre, prospective cohort study. Crit Care. 2015 Feb;19:81.

  • Green A, Australian Intensive Care Unit Liaison Nurse Investigator Forum, Jones D, McIntyre T, Taylor C, Chaboyer W, Bailey M. Characteristics and outcomes of patients reviewed by intensive care unit liaison nurses in Australia: a prospective multicentre study. Crit Care Resusc. 2015 Dec;17(4):244-252.

  • Iwashyna TJ, Hodgson CL, Pilcher D, Orford N, Santamaria JD, Bailey M, Bellomo R. Towards defining persistent critical illness and other varieties of chronic critical illness. Crit Care Resusc. 2015 Sep;17(3):215-218.

  • Bihari S, , Deane A, Fuchs R, Fraser J, Bersten AD, Bellomo R. Preclinical research in critical care - the Australasian perspective. Crit Care Resusc. 2015 Sep;17(3):151-152.

  • Hammond NE, Taylor C, Saxena M, Liu B, Finfer S, Glass P, Seppelt I, Willenberg L, Myburgh J. Resuscitation fluid use in Australian and New Zealand Intensive Care Units between 2007 and 2013. Intensive Care Med. 2015 Sep;41(9):1611-1619.

  • Doig GS, Simpson F, Heighes PT, Bellomo R, Chesher D, Caterson ID, Reade MC, Harrigan PW; Refeeding Syndrome Trial Investigators Group. Restricted versus continued standard caloric intake during the management of refeeding syndrome in critically ill adults: a randomised, parallel-group, multicentre, single-blind controlled trial. The Lancet Respiratory medicine. 2015 Dec;3(12):943-952.

  • Doig GS, Simpson F, Bellomo R, Heighes PT, Sweetman EA, Chesher D, Pollock C, Davies A, Botha J, Harrigan P, Reade MC. Intravenous amino acid therapy for kidney function in critically ill patients: a randomized controlled trial. Intensive Care Med. 2015 Jul;41(7):1197-1208.

 

2014

  •  

    Orford NR, Bailey M, Kaukonen K, Elderkin T, Stow P, Cattigan C, Kotowicz M, Bellomo R. Glycaemic control and long-term outcomes following transition from modified intensive insulin therapy to conventional glycaemic control. Anaesth Intensive Care . 2014 Mar;42(2):239-247.

  •  

    Orford N, Cattigan C, Brennan SL, Kotowicz M, Pasco J, Cooper DJ. The association between critical illness and changes in bone turnover in adults: a systematic review. Osteoporos Int. 2014 Oct;25(10):2335-2346.

  •  

    Simpson RW, Nicholson GC, Proietto J, Sarah A, Sanders KM, Phillips G, Chambers J, MacGinley R, Orford N, Walder K, Krippner G, Skoff K, Wacher VJ. Efficacy and safety of oral methazolamide in patients with type 2 diabetes: a 24-week, placebo-controlled, double-blind study. Diabetes Care. 2014 Nov;37(11):3121-3123.

  •  

    Phillips L, Orford N, Ragg M. Prospective observational study of emergent endotracheal intubation practice in the intensive care unit and emergency department of an Australian regional tertiary hospital. Emerg Med Australas. 2014 Aug;26(4):368-375.

  •  

    Fowler RA, Mittmann N, Geerts WH, Heels-Ansdell D, Gould MK, Guyatt G, Krahn M, Finfer S, Pinto R, Chan B, Ormanidhi O, Arabi Y, Qushmaq I, Rocha MG, Dodek P, McIntyre L, Hall R, Ferguson ND, Mehta S, Marshall JC, Doig CJ, Muscedere J, Jacka MJ, Klinger JR, Vlahakis N, Orford N, Seppelt I, Skrobik YK, Sud S, Cade JF, Cooper J, Cook D, Canadian Critical Care Trials Group, Australia and New Zealand Intensive Care Society Clinical Trials Group. Economic evaluation of the prophylaxis for thromboembolism in critical care trial (E-PROTECT): study protocol for a randomized controlled trial. Trials . 2014 Dec;15:502.

  •  

    Fowler RA, ittmann N, Geerts W, Heels-Ansdell D, Gould MK, Guyatt G, Krahn M, Finfer S, Pinto R, Chan B, Ormanidhi O, Arabi Y, Qushmaq I, Rocha MG, Dodek P, McIntyre L, Hall R, Ferguson ND, Mehta S, Marshall JC, Doig CJ, Muscedere J, Jacka MJ, Klinger JR, Vlahakis N, Orford N, Seppelt I, Skrobik YK, Sud S, Cade JF, Cooper J, Cook D, Canadian Critical Care Trials Group, Australia and New Zealand Intensive Care Society Clinical Trials Group. Cost-effectiveness of dalteparin vs unfractionated heparin for the prevention of venous thromboembolism in critically ill patients. JAMA. 2014 Nov;312(20):2135-2145.

  •  

    Peake SL, Delaney A, Bailey M, Bellomo R, Cameron PA, Cooper DJ, Higgins AM, Holdgate A, Howe BD, Webb SA, Williams P. Goal-directed resuscitation for patients with early septic shock. N Engl J Med. 2014 Oct;371(16):1496-1506.

  •  

    Wang AY, Bellomo R, Ninomiya T, Lo S, Cass A, Jardine M, Gallagher M; RENAL Study Investigators; ANZICS Clinical Trials Group. Angiotensin-converting enzyme inhibitor usage and acute kidney injury: a secondary analysis of RENAL study outcomes. Nephrology. 2014 Oct;19(10):617-622.

  •  

    Jun M, Bellomo R, Cass A, Gallagher M, Lo S, Lee J; Randomized Evaluation of Normal Versus Augmented Level of Replacement Therapy (RENAL) Study Investigators. Timing of renal replacement therapy and patient outcomes in the randomized evaluation of normal versus augmented level of replacement therapy study. Crit Care Med. 2014 Aug;42(8):1756-1765.

  •  

    Bellomo R, Cass A, Cole L, Finfer S, Gallagher M, Lee J, Lo S, McArthur C, McGuinness S, Norton R, Myburgh J, Sheinkestel C; RENAL Study Investigators. Daily protein intake and patient outcomes in severe acute kidney injury: findings of the randomized evaluation of normal versus augmented level of replacement therapy (RENAL) trial. Blood Purif. 2014 Aug;37(4):325-334.

 

  •  

    Crowther M, Cook D, Guyatt G, Zytaruk N, McDonald E, Williamson D, Albert M, Dodek P, Finfer S, Vallance S, Heels-Ansdell D, McIntyre L, Mehta S, Lamontagne F, Muscedere J, Jacka M, Lesur O, Kutsiogiannis J, Friedrich J, Klinger JR, Qushmaq I, Burry L, Khwaja K, Sheppard JA, Warkentin TE; PROTECT collaborators; Canadian Critical Care Trials Group; Australian and New Zealand Intensive Care Society Clinical Trials Group. Heparin-induced thrombocytopenia in the critically ill: interpreting the 4Ts test in a randomized trial. J Crit Care. 2014 June;29(3):470 e477-415.

  •  

    Gallagher M, Cass A, Bellomo R, Finfer S, Gattas D, Lee J, Lo S, McGuinness S, Myburgh J, Parke R, Rajbhandari D, POST-RENAL Study Investigators and the ANZICS Clinical Trials Group. Long-term survival and dialysis dependency following acute kidney injury in intensive care: extended follow-up of a randomized controlled trial. PLoS medicine. 2014 Feb;11(2):e1001601.

  •  

    Nunnink L, Foot C, Venkatesh B, Corke C, Saxena M, Lucey M, Jones M. High-stakes assessment of the non-technical skills of critical care trainees using simulation: feasibility, acceptability and reliability. Crit Care Resusc. 2014 Mar;16(1):6-12.

  •  

    Detering K, Silvester W, Corke C, Milnes S, Fullam R, Lewis V, Renton J. Teaching general practitioners and doctors-in-training to discuss advance care planning: evaluation of a brief multimodality education programme. BMJ supportive & palliative care. 2014 Sep;4(3):313-321.

  •  

    Kaukonen KM, Bailey M, Egi M, Orford N, Glassford NJ, Marik PE, Bellomo R. Stress hyperlactatemia modifies the relationship between stress hyperglycemia and outcome: a retrospective observational study. Crit Care Med. 2014 June;42(6):1379-1385.

2013

  • Bucca K, Spencer R, Orford N, Cattigan C, Athan E, McDonald A. Early diagnosis and treatment of necrotizing fasciitis can improve survival: an observational intensive care unit cohort study. ANZ J Surg. 2013 May;83(5):365-70.

  • Brieva J, Coleman N, Lacey J, Harrigan P, Lewin TJ, Carter GL. Prediction of death in less than 60 minutes following withdrawal of cardiorespiratory support in ICUs. Crit Care Med. 2013 Dec;41(12):2677-2687.

  • Cook D, Arabi Y, Ferguson N, Heels-Ansdell D, Freitag A, McDonald E, Clarke F, Keenan S, Pagliarello G, Plaxton W, Herridge M, Karachi T, Vallance S, Cade J, Crozier T, Alves da Silva S, Costa Filho R, Brandao N, Watpool I, McArdle T, Hollinger G, Mandourah Y, Al-Hazmi M, Zytaruk N, Adhikari NK; PROTECT Coordinators; PROTECT Investigators; Canadian Critical Care Trials Group, Australian and New Zealand Intensive Care Society Clinical Trials Group. Physicians declining patient enrollment in a critical care trial: a case study in thromboprophylaxis. Intensive Care Med. 2013 Dec;39(12):2115-2125.

  • Parke RL, Eastwood GM, McGuinness SP; George Institute for Global Health; Australian and New Zealand Intensive Care Society Clinical Trials Group. Oxygen therapy in non-intubated adult intensive care patients: a point prevalence study. Crit Care Resusc. 2013 Dec;15(4):287-293.

  • Bihari S, Peake SL, Seppelt I, Williams P, Bersten A; George Institute for Global Health; Australian and New Zealand Intensive Care Society Clinical Trials Group. Sodium administration in critically ill patients in Australia and New Zealand: a multicentre point prevalence study. Crit Care Resusc. 2013 Dec;15(4):294-300.

  • Berney SC, Harrold M, Webb SA, Seppelt I, Patman S, Thomas PJ, Denehy L. Intensive care unit mobility practices in Australia and New Zealand: a point prevalence study. Crit Care Resusc. 2013 Dec;15(4):260-265.

  • Williamson DR, Albert M, Heels-Ansdell D, Arnold DM, Lauzier F, Zarychanski R, Crowther M, Warkentin TE, Dodek P, Cade J, Lesur O, Lim W, Fowler R, Lamontagne F, Langevin S, Freitag A, Muscedere J, Friedrich JO, Geerts W, Burry L, Alhashemi J, Cook D; PROTECT collaborators; Canadian Critical Care Trials Group, Australian and New Zealand Intensive Care Society Clinical Trials Group. Thrombocytopenia in critically ill patients receiving thromboprophylaxis: frequency, risk factors, and outcomes. Chest . 2013 Oct;144(4):1207-1215.

  • Hammond NE, Saxena MK, Taylor C, Young P, Seppelt I, Glass P, Myburgh J, George Institute for Global Health; Australian and New Zealand Intensive Care Society Clinical Trials Group. Temperature management of non-elective intensive care patients without neurological abnormalities: a point prevalence study of practice in Australia and New Zealand. Crit Care Resusc. 2013 Sep;15(3):228-233.

  • Elliott D, Aitken LM, Bucknall TK, Seppelt IM, Webb SA, Weisbrodt L, McKinley S; Australian and New Zealand Intensive Care Society Clinical Trials Group; George Institute for Global Health. Patient comfort in the intensive care unit: a multicentre, binational point prevalence study of analgesia, sedation and delirium management. Crit Care Resusc. 2013 Sep;15(3):213-219.

  • Warkentin TE, Sheppard JA, Heels-Ansdell D, Marshall JC, McIntyre L, Rocha MG, Mehta S, Davies AR, Bersten AD, Crozier TM, Ernest D, Vlahakis NE, Hall RI, Wood GG, Poirier G, Crowther MA, Cook DJ; Canadian Critical Care Trials Group, Australian and New Zealand Intensive Care Society Clinical Trials Group. Heparin-induced thrombocytopenia in medical surgical critical illness. Chest . 2013 Sep;144(3):848-858.

  • Doig GS, Simpson F, Sweetman EA, Finfer SR, Cooper DJ, Heighes PT, Davies AR, O'Leary M, Solano T, Peake S, Early PN Investigators of the ANZICS Clinical Trials Group. arly parenteral nutrition in critically ill patients with short-term relative contraindications to early enteral nutrition: a randomized controlled trial. JAMA. 2013 May;309(20):2130-2138.

  • Kruger P, Bailey M, Bellomo R, Cooper DJ, Harward M, Higgins A, Howe B, Jones D, Joyce C, Kostner K, McNeil J, Nichol A, Roberts MS, Syres G, Venkatesh B; ANZ-STATInS Investigators – ANZICS Clinical Trials Group. A multicenter randomized trial of atorvastatin therapy in intensive care patients with severe sepsis. Am J Respir Crit Care Med. 2013 April;187(7):743-750.

  • Bellomo R, Lipcsey M, Calzavacca P, Haase M, Haase-Fielitz A, Licari E, Tee A, Cole L, Cass A, Finfer S, Gallagher M, Lee J, Lo S, McArthur C, McGuinness S, Myburgh J, Scheinkestel C; RENAL Study Investigators and ANZICS Clinical Trials Group. Early acid-base and blood pressure effects of continuous renal replacement therapy intensity in patients with metabolic acidosis. Intensive Care Med. 2013 Mar;39(3):429-436.

  • Smith OM, McDonald E, Zytaruk N, Foster D, Matte A, Clarke F, Meade L, O'Callaghan N, Vallance S, Galt P, Rajbhandari D, Rocha M, Mehta S, Ferguson ND, Hall R, Fowler R, Burns K, Qushmaq I, Ostermann M, Heels-Ansdell D, Cook D; PROTECT Research Coordinators, PROTECT Investigators, Canadian Critical Care Trials Group, Australian, New Zealand Intensive Care Society Clinical Trials Group. Rates and determinants of informed consent: a case study of an international thromboprophylaxis trial. J Crit Care. 2013 Feb;8(1):28-39.

  • Cook D, McDonald E, Smith O, Zytaruk N, Heels-Ansdell D, Watpool I, McArdle T, Matte A, Clarke F, Vallance S, Finfer S, Galt P, Crozier T, Fowler R, Arabi Y, Woolfe C, Orford N, Hall R, Adhikari NK, Ferland MC, Marshall J, Meade M; PROTECT Research Coordinators, PROTECT Investigators, Canadian Critical Care Trials Group, Australian and New Zealand Intensive Care Society Clinical Trials Group. Co-enrollment of critically ill patients into multiple studies: patterns, predictors and consequences. Crit Care. 2013 NO;17:R1.

  • Vincent JL, Ramesh MK, Ernest D, LaRosa SP, Pachl J, Aikawa N, Hoste E, Levy H, Hirman J, Levi M, Daga M, Kutsogiannis DJ, Crowther M, Bernard GR, Devriendt J, Puigserver JV, Blanzaco DU, Esmon CT, Parrillo JE, Guzzi L, Henderson SJ, Pothirat C, Mehta P, Fareed J, Talwar D, Tsuruta K, Gorelick KJ, Osawa Y, Kaul I. A randomized, double-blind, placebo-controlled, Phase 2b study to evaluate the safety and efficacy of recombinant human soluble thrombomodulin, ART-123, in patients with sepsis and suspected disseminated intravascular coagulation. Crit Care Med. 2013 Sep;41(9):2069-2079.

  • Esteban A, Frutos-Vivar F, Muriel A, Ferguson ND, Penuelas O, Abraira V, Raymondos K, Rios F, Nin N, Apezteguia C, Violi DA, Thille AW, Brochard L, Gonzalez M, Villagomez AJ, Hurtado J, Davies AR, Du B, Maggiore SM, Pelosi P, Soto L, Tomicic V, D'Empaire G, Matamis D, Abroug F, Moreno RP, Soares MA, Arabi Y, Sandi F, Jibaja M, Amin P, Koh Y, Kuiper MA, Bulow HH, Zeggwagh AA, Anzueto A. Evolution of mortality over time in patients receiving mechanical ventilation. Am J Respir Crit Care Med. 2013 Jul;188(2):220-230.

  • Chaboyer W, Chamberlain D, Hewson-Conroy K, Grealy B, Elderkin T, Brittin M, McCutcheon C, Longbottom P, Thalib L. CNE article: safety culture in Australian intensive care units: establishing a baseline for quality improvement. Am J Crit Care . 2013 Mar;22(2):93-102.

2012

  • Davies AR, Morrison SS, Bailey MJ, Bellomo R, Cooper DJ, Doig GS, Finfer SR, Heyland DK; ENTERIC Study Investigators; ANZICS Clinical Trials Group. A multicenter, randomized controlled trial comparing early nasojejunal with nasogastric nutrition in critical illness. Crit Care Med. 2012 Aug;40(8):2342-2348.

  • Myburgh JA, Finfer S, Bellomo R, Billot L, Cass A, Gattas D, Glass P, Lipman J, Liu B, McArthur C, McGuinness S, Rajbhandari D, Taylor CB, Webb SA; CHEST Investigators; Australian and New Zealand Intensive Care Society Clinical Trials Group. Hydroxyethyl starch or saline for fluid resuscitation in intensive care. N Engl J Med. 2012 Nov;367(20):1901-1911.

  • Bellomo R, Cass A, Cole L, Finfer S, Gallagher M, Lee J, Lo S, McArthur C, McGuiness S, Norton R, Myburgh J, Scheinkestel C, Su S. An observational study fluid balance and patient outcomes in the Randomized Evaluation of Normal vs. Augmented Level of Replacement Therapy trial. Crit Care Med. 2012 June;40(6):1753-1760.

  • Peake SL, Chapman MJ, Davies AR, Moran JL, O'Connor S, Ridley E, Williams P; George Institute for Global Health, Australian and New Zealand Intensive Care Society Clinical Trials Group. Enteral nutrition in Australian and New Zealand intensive care units: a point-prevalence study of prescription practices. Crit Care Resus. 2012 June;14(2):148-153.

  • Ranieri VM, Thompson BT, Barie PS, Dhainaut JF, Douglas IS, Finfer S, Gardlund B, Marshall JC, Rhodes A, Artigas A, Payen D, Tenhunen J, Al-Khalidi HR, Thompson V, Janes J, Macias WL, Vangerow B, Williams MD; PROWESS-SHOCK Study Group. Drotrecogin alfa (activated) in adults with septic shock. N Engl J Med. 2012 May;366(22):2055-2064

 

2011 and before 

  • Orford NR, Saunders K, Merriman E, Henry M, Pasco J, Stow P, Kotowicz M. Skeletal morbidity among survivors of critical illness. Crit Care Med. 2011 June;39(6):1295-1300.

  • Pettila V, Webb SA, Bailey M, Howe B, Seppelt IM, Bellomo R. Acute kidney injury in patients with influenza A (H1N1) 2009. Intensive Care Med. 2011 May;37(5):763-767.

  • Cook D, Meade M, Guyatt G, Walter S, Heels-Ansdell D, Warkentin TE, Zytaruk N, Crowther M, Geerts W, Cooper DJ, Vallance S, Qushmaq I, Rocha M, Berwanger O, Vlahakis NE. Dalteparin versus unfractionated heparin in critically ill patients. N Engl J Med. 2011 April;364(14):1305-1314.

  • Davies AR, Morrison SS, Ridley EJ, Bailey M, Banks MD, Cooper DJ, Hardy G, McIlroy K, Thomson A, ASAP Study Investigators. Nutritional therapy in patients with acute pancreatitis requiring critical care unit management: a prospective observational study in Australia and New Zealand. Crit Care Med. 2011 Mar;39(3):462-468.

  • Knight M, Pierce M, Seppelt I, Kurinczuk JJ, Spark P, Brocklehurst P, McLintock C, Sullivan E; UK's Obstetric Surveillance System, the ANZIC Influenza Investigators, Australasian Maternity Outcomes Surveillance System. Critical illness with AH1N1v influenza in pregnancy: a comparison of two population-based cohorts. BJOG. 2011 Jan;118(2):232-239.

  • Pettila V, Westbrook AJ, Nichol AD, Bailey MJ, Wood EM, Syres G, Phillips LE, Street A, French C, Murray L, Orford N, Santamaria JD, Bellomo R, Cooper DJ; Blood Observational Study Investigators for ANZICS Clinical Trials Group. Age of red blood cells and mortality in the critically ill. Crit Care. 2011 NO;15(2):R116.

  • Renton J, Pilcher DV, Santamaria JD, Stow P, Bailey M, Hart G, Duke G. Factors associated with increased risk of readmission to intensive care in Australia. Intensive Care Med. 2011 Nov;37(11):1800-1808.

  • Bucknall TK, Jones D, Barrett J, Bellomo R, Botti M, Considine J, Currey J, Dunning TL, Green D, Levinson M, Livingston PM, O'Connell B, Ruseckaite R, Staples M. Point prevalence of patients fulfilling MET criteria in ten MET equipped hospitals. The methodology of the RESCUE study. Resuscitation . 2011 May;82(5):529-534.

  • Corke C, Silvester W, Bellomo R. Avoiding nosocomial dysthanasia and promoting eleothanasia. Crit Care Resusc. 2010 Dec;12(14):221-222.

  • Westbrook A, Pettila V, Nichol A, Bailey MJ, Syres G, Murray L, Bellomo R, Wood E, Phillips LE, Street A, French C, Orford N, Santamaria J, Cooper DJ. Transfusion practice and guidelines in Australian and New Zealand intensive care units. Intensive Care Med. 2010 Jul;36(7):1138-1146.

  • Chen J, Bellomo R, Hillman K, Flabouris A, Finfer S; MERIT Study Investigators for the Simpson Centre and the ANZICS Clinical Trials Group. Triggers for emergency team activation: a multicenter assessment. J Crit Care. 2010 June;25(2):359.e1-7.

  • ANZIC Influenza Investigators and Australasian Maternity Outcomes Surveillance System, NO. Critical illness due to 2009 A/H1N1 influenza in pregnant and postpartum women: population based cohort study. BMJ . 2010 Mar;340:c1279.

  • Flabouris A, Chen J, Hillman K, Bellomo R, Finfer S; MERIT Study Investigators from the Simpson Centre and the ANZICs Clinical Trials Group. Timing and interventions of emergency teams during the MERIT study. Resuscitation . 2010 Jan;81(1):25-30.

  • Rose L, Baldwin I, Crawford T, Parke R. Semirecumbent positioning in ventilator-dependent patients: a multicenter, observational study. Am J Crit Care. 2010 Nov;19(6):e100-108.

  • Rose L, Baldwin I, Crawford T. The use of bed-dials to maintain recumbent positioning for critically ill mechanically ventilated patients (The RECUMBENT study): multicentre before and after observational study. Int J Nurs Stud. 2010 Nov;47(11):1425-1431

  • Corke C, Mann J. Effect of a supplement clarifying patients' intentions on doctors' willingness to follow the wishes of an agent with medical enduring power of attorney. Crit Care Resusc. 2009 Sep;11(3):215-218.

  • Corke C, Milnes S, Orford N, Henry MJ, Foss C, Porter D. The influence of medical enduring power of attorney and advance directives on decision-making by Australian intensive care doctors. Crit Care Resusc. 2009 June;11(2):122-128.

  • Corke C, Leeuw E, Lo SK, George C. Predicting future intensive care demand in Australia. Crit Care Resusc. 2009 Dec;11(4):257-260.

  • Bolsin SN, Raineri F, Lo SK, Cattigan C, Arblaster R, Colson M. Cardiac complications and mortality rates in diabetic patients following non-cardiac surgery in an Australian teaching hospital. Anaesth Intensive Care. 2009 Jul;37(4):561-567.

  • Chen J, Flabouris A, Bellomo R, Hillman K, Finfer S, MERIT Study Investigators from the Simpson Centre; ANZICS Clinical Trial Group. Baseline hospital performance and the impact of medical emergency teams: modelling vs. conventional subgroup analysis. Trials . 2009 Dec;10:117.

  • Vincent JL, Rello J, Marshall J, Silva E, Anzueto A, Martin CD, Moreno R, Lipman J, Gomersall C, Sakr Y, Reinhart K, EPIC II Group of Investigators. International study of the prevalence and outcomes of infection in intensive care units. JAMA . 2009 Dec;302(21):2323-2329.

  • Webb SA, Pettila V, Seppelt I, Bellomo R, Bailey M, Cooper DJ, Cretikos M, Davies AR, Finfer S, Harrigan PW, Hart GK, Howe B, Iredell JR, McArthur C, Mitchell I, Morrison S, Nichol AD, Paterson DL, Peake S, Richards B, Stephens D, Turner A, Yung M. Critical care services and 2009 H1N1 influenza in Australia and New Zealand. N Engl J Med. 2009 Nov;361(20):1925-1934.

  • Bellomo R, Cass A, Cole L, Finfer S, Gallagher M, Lo S, McArthur C, McGuinness S, Myburgh J, Norton R, Scheinkestel C, Su S. Intensity of continuous renal-replacement therapy in critically ill patients. N Engl J Med. 2009 Oct;361(17):1627-1638.

  • Chen J, Bellomo R, Flabouris A, Hillman K, Finfer S; MERIT Study Investigators from the Simpson Centre; ANZICS Clinical Trials Group. he relationship between early emergency team calls and serious adverse events. Crit Care Med. 2009 Jan;37(1):148-153.

  • Chen J, Hillman K, Bellomo R, Flabouris A, Finfer S, Cretikos M; MERIT Study Investigators for the Simpson Centre; ANZICS Clinical Trials Group. The impact of introducing medical emergency team system on the documentations of vital signs. Resuscitation . 2009 Jan;80(1):35-43

  • Orford NR, Faulkner C, Flintoff W, Eddey D, Lamb-Jenkins J, Henry M, Corke C, Stow P, Green D. Implementation and outcomes of a severe sepsis protocol in an Australian tertiary hospital. Crit Care Resusc. 2008 Sep;10(3):217-224.

  • Chen J, Flabouris A, Bellomo R, Hillman K, Finfer S; MERIT Study Investigators for the Simpson Centre and the ANZICS Clinical Trials Group. The Medical Emergency Team System and not-for-resuscitation orders: results from the MERIT study. Resuscitation . 2008 Dec;79(3):391-397.

  • RENAL Study Investigators, NO. Renal replacement therapy for acute kidney injury in Australian and New Zealand intensive care units: a practice survey. Crit Care Resusc. 2008 Sep;10(3):225-30.

  • Dulhunty JM, Lipman J, Finfer S; Sepsis Study Investigators for the ANZICS Clinical Trials Group. Does severe non-infectious SIRS differ from severe sepsis? Results from a multi-centre Australian and New Zealand intensive care unit study. Intensive Care Med. 2008 Sep;34(9):1654-1661

  • Cretikos MA, Chen J, Hillman KM, Bellomo R, Finfer SR, Flabouris A; MERIT Study Investigators. The effectiveness of implementation of the medical emergency team (MET) system and factors associated with use during the MERIT study. Crit Care Resusc. 2007 June;9(7):205-212.

  • Cretikos M, Chen J, Hillman K, Bellomo R, Finfer S, Flabouris A; MERIT Study Investigators. The objective medical emergency team activation criteria: a case-control study. Resuscitation . 2007 April;73(1):62-72.

  • Orford NR, NO. Intensive insulin therapy in septic shock. Crit Care Resusc. 2006 Sep;8(3):230-234.

  • Orford N, NO. Intensive insulin therapy: does it improve outcomes and is it safe?. Crit Care Resusc. 2006 Dec;8(4):281.

  • Fraser TA, Corke CF, Mohajeri M, Stevenson L, Campbell PJ. A retrospective audit of the use of Prothrombinex-HT for refractory bleeding following adult cardiac surgery. Crit Care Resusc. 2006 June;8(2):141-145.

  • Finfer S, Felton T, Blundell A, Lipman J, Investigators ANZICS Clinical Trials Group Sepsis Investigators. Estimate of the number of patients eligible for treatment with drotrecogin alfa (activated) based on differing international indications: post-hoc analysis of an inception cohort study in Australia and New Zealand. Anaesth Intensive Care. 2006 April;34(2):184-190

  • Cooper DJ, Bishop N, Cade J, Finfer S, Gallus A, Myburgh J; Australian and New Zealand Intensive Care Society Clinical Trials Group. Thromboprophylaxis for intensive care patients in Australia and New Zealand: a brief survey report. J Crit Care. 2005 Dec;20(4):354-356.

  • Hillman K, Chen J, Cretikos M, Bellomo R, Brown D, Doig G, Finfer S, Flabouris A; MERIT Study Investigators. Introduction of the medical emergency team (MET) system: a cluster-randomised controlled trial. Lancet. 2005 June;365(9477):2091-2097.

  • Orford N, Stow P, Green D, Corke C. Safety and feasibility of an insulin adjustment protocol to maintain blood glucose concentrations within a narrow range in critically ill patients in an Australian level III adult intensive care unit. Crit Care Resusc. 2004 June;6(2):92-98.

  • Kause J, Smith G, Prytherch D, Parr M, Flabouris A, Hillman K; Intensive Care Society (UK), Australian and New Zealand Intensive Care Society Clinical Trials Group. A comparison of antecedents to cardiac arrests, deaths and emergency intensive care admissions in Australia and New Zealand, and the United Kingdom--the ACADEMIA study. Resuscitation. 2004 Sep;62(3):275-282.

  • Finfer S, Bellomo R, Lipman J, French C, Dobb G, Myburgh J. dult-population incidence of severe sepsis in Australian and New Zealand intensive care units. Intensive Care Med. 2004 Apr;30(4):589-596.

ANZICS Clinical Trials Group and Collaborative Studies

Current studies

  • STARRT AKI: Standard versus accelerated initiation of renal replacement therapy in acute kidney injury
  • TEAM: Trial of early activity and mobilisation in ICU (TEAM)
  • ARTPN: Australasian registry of the use of parenteral nutrition in hospitalised patients.
  • LUCID: A phase II study of Liberal Glucose Control in Critically Ill Patients with pre-existing type 2 diabetes 
  • ProMEDIC: Prophylactic melatonin for the prevention of delirium in intensive care 
  • REMAP-CAP:  Randomised embedded, multifactorial adaptive platform trial for community-acquired pneumonia 
  • BLENDER: Blend to Limit oxygEN in ECMO: a ranDomised controllEd Registry trial The BLENDER Trial – A Phase II Multicentre Randomised Controlled Trial
  • EXCEL: A comprehensive national registry on the treatment and outcomes of patients requiring ECMO
  • Exogenous vitamin B1 (thiamine) administration in enterally-fed critically ill patients with hypophosphatemia

Completed Studies

  • BLING III: A phase III randomised controlled trial of continuous betalactam infusion compared with intermittent beta-lactamdosing in critically ill patients (BLING-III)
  • VITAMINS: The vitamin C, hydrocortisone and thiamine in patients with septic shock trial 
  • PROTECTIN - PROspective TrEatment to Counter the Systemic InflammaTory Response Syndrome with AspirIN
  • SPLIT - A Pilot, Randomised, blinded, multicentre, feasibility, safety and biochemical and physiological efficacy study of normal saline vs. plasmalyte in Intensive therapy
  • ADRENAL - Adjunctive corticosteroid treatment in critically ill patients with septic shock
  • PHARLAP - A multi-centre randomised controlled trial of an Open Lung Strategy including Permissive Hypercapnia, Alveolar Recruitment and Low Airway Pressure in patients with acute respiratory distress syndrome
  • SPICE III - Sedation Practices in Intensive Care Evaluation - Early Goal Directed Sedation Compared with Standard Care in Mechanically Ventilated Patients in Intensive Care
  • TRANSFUSE – Standard Issue Transfusion versus fresher red blood cell use in intensive care - a randomized controlled trial
  • Neb-Hep ALI - Nebulised Heparin for Lung Injury
  • Supp PN - Supplemental Parenteral Nutrition in Critically Ill Patients, A Pilot Randomised Controlled Study
  • Enteric
  • PROTECT
  • RENAL
  • Early PN
  • Nephroprotect
  • CHEST
  • MERIT
Commercial Trials

 

Completed

  • PROWESS-SHOCK
  • ATIII
  • ASPECT - A Prospective, Randomized, Double-Blind, Multicenter, Phase 3 Study to Assess the Safety and Efficacy of Intravenous Ceftolozane/tazobactam compared With Meropenem in Adult Patients with Ventilated Nosocomial Pneumonia
UHG ICU Led Research Programs

Softer - Skeletal Outcomes After Critical Illness

The Softer program aims to investigate the relationship between critical illness and accelerated bone loss, associated morbidity, and potential beneift of anti-fracure therapies. 

  • Orford N, Bailey M, Bellomo R, Pasco JA, Cattigan C, Elderkin T, Bone A, Cooper DJ, Maiden M, NiChinghaile M, Kakho N, Jones C, Hodgson C, Kotowicz MEffect of denosumab on bone turnover markers in critically ill women - A safety and feasibility, randomised, placebo, controlled trial. 
  • Orford NR, Bailey M, Bellomo R, Pasco JA, Cattigan C, Elderkin T, Brennan-Olsen S, Kotowicz M. The association of time and medications with changes in bone mineral density in the 2 years after critical illness. Crit Care. 2017;21(1):69. doi:10.1186/s13054-017-1657-6.
  • Orford NR, Lane SE, Bailey M, et al. Changes in Bone Mineral Density in the Year After Critical Illness. Am J Respir Crit Care Med. November 2015:rccm.201508–1514OC. doi:10.1164/rccm.201508-1514OC. 
  • Orford N, Cattigan C, Brennan SL, Kotowicz M, Pasco J, Cooper DJ. The association between critical illness and changes in bone turnover in adults: a systematic review. Osteoporos Int. 2014;25(10):2335-2346. doi:10.1007/s00198-014-2734-1.
  • Orford N, Saunders K, Merman E, Henry M, Pasco J, Stow P, Kotowicz M. Skeletal morbidity among survivors of critical illness. Crit Care Med. 2011 39(6);1295-1300.

 

i-validate - identifying values, listening, and advising high-risk patients in acute care

  • Orford N, Milnes S, Simpson N, Keely G, Elderkin T, Bone A, Martin P, Bellomo R, Bailey M, Corke C.   Effect of communication skills training on outcomes in critically ill patients with life-limiting illness referred for intensive care management – A before-and-after study. BMJSPCare. 2017, under review.

  • Milnes S, Corke C, Orford NR, Bailey M, Savulescu J, Wilkinson D. Patient values informing medical treatment: a pilot community and advance care planning surveyBMJ Supportive & Palliative Care. March 2017:bmjspcare–2016–001177. doi:10.1136/bmjspcare-2016-001177 

  • Orford N, Milnes S, Lambert N, Berkeley L, Lane S, Simpson N, Eldurkin T, Bone A, Mrtin P, Corke C, Bellow R, Bailey M. Prevalence, goals of care discussions, and long-term outcomes of patients with life-limiting illness referred to intensive care. Crit Care Resusc. Accepted for publication Mar 2016
  • Milnes S, Orford NR, Berkeley L, et al. A prospective observational study of prevalence and outcomes of patients with Gold Standard Framework criteria in a tertiary regional Australian Hospital. BMJ Supportive & Palliative Care. September 2015:1-9. doi:10.1136/bmjspcare-2015.
  • Corke C, Milnes S, Orford N, Henry MJ, Foss C, Porter D. The influence of medical enduring power of attorney and advance directives on decision-making by Australian intensive care doctors. Crit Care Resusc. 2009;11(2):122-128.

 

Long-term Outcomes after Critical Illness

  • Iwashyna TJ, Hodgson CL, Pilcher D, Orford N, et al. Towards defining persistent critical illness and other varieties of chronic critical illness. Crit Care Resusc. 2015;17(3):215-218.

 

Data linkage - the SLIC ICU database

  • Entesari-Tatafi D, Orford N, Bailey MJ, Chonghaile MNI, Lamb-Jenkins J, Athan E. Effectiveness of a care bundle to reduce central line-associated bloodstream infections. Med J Aust. 2015;202(5):247-249. doi:10.5694/mja14.01644.
  • Orford NR, Bailey M, Kaukonen K, et al. Glycaemic control and long-term outcomes following transition from modified intensive insulin therapy to conventional glycaemic control. Anaesth Intensive Care. 2014;42(2):239-247
  • Kaukonen K-M, Bailey M, Egi M, Orford N, et al. Stress hyperlactatemia modifies the relationship between stress hyperglycemia and outcome: a retrospective observational study. Crit Care Med. 2014;42(6):1379-1385. doi:10.1097/CCM.
  • Kaukonen KM, Bailey M, Pilcher D, Orford N, et al. Choosing the correct merits for glucose control. Authors reply. Crit Care. 2014 Mar 5;18(2):414
  • Kaukonen K-M, Bailey M, Pilcher D, Orford N, Finfer S, Bellomo R. Glycaemic control in Australia and New Zealand before and after the NICE-SUGAR trial: a translational study. Crit Care. 2013;17(5):R215. doi:10.1186/cc13030
Abstracts/Posters
Presentations and Podcasts

2019

  • Oct: Orford NR. WCICM Plenary: Strengthening Teams through better EOLC.
  • Oct: Orford NR.  WCICM: From Critical to Broken - Bone Loss after Critical Illness
  • Apr: Orford NR. CICM Trainee Day: Advice from an ICU Director
  • Mar: Orford NR. ANZICS CTG ASM: Antiresorptive Agents in Critical Illness

2018

  • Mar: Orford NR. ICU survivors, ANZICS CTG ASM
  • Apr: Orford NR. What a Director looks for, CICM Vic Training Evening
  • Jul: Orford NR. The iValidate Program, SVH Sydney.
  • Aug: Orford NR. CICM New Fellows Conference

 

2017

  • Feb: Orford N, i-validate and i-lead, Intensive Care Network Meeting, Melbourne
  • May: Orford N, Identifying patients who have a poor prognosis. CICM ASM ICU Update, Sydney
  • June: Orford N, Should we do End of Life research in ICU?, Monash Research Meeting, Prato
  • August: Orford N, Improving communication with the dying, ANZICS SQ Conference, Sydney
  • Augist: Orford N, Leadership In ICU,  CICM New Fellow Conference, Byron Bay
  • Sept: Orford N, The ivalidate program: Masters of Clinical Leadership Residential Program, Deakin University
2016
  • Orford N, Setting up a Regional ECMO Program, GC ECMO Seminar
  • Orford N, Phase 2 pilot interventional trial of denosumab to prevent bone loss in older female survivors of critical illness. VICTORI Group, Melbourne.
  • Orford N, End-of-life Care and Mechanical Ventilation. 10th Advanced Mechanical Ventilation Conference (AAMVC), Melbourne. 
  • Orford N, Lessons from a Regional ECMO Program. ECMO longtable dinner, Brisbane.
  • Orford N, The i-validate program 2016, Melbourne. EACH Conference Melbourne.
2015
  • Orford N, Effect of critical illness on bone turnover. ANZICS CTG ASM, Noosa. 
  • Orford N, JAMA geddon – Journal Club. ANZICS ASM, Auckland. 
  • Orford N, End-of-life care in ICU. ANZICS ASM, Auckland.
  • Orford N, Social media and critical care. ANZICS ASM, Auckland. 
  • Orford N, 9x9 - Antivirals and critical illness. ANZICS ASM, Auckland.
  • Orford N, What a Director looks for in a junior consultant. CICM ASM, Darwin. 
2014
  • Orford N, A guide to mechanical ventilation during ECMO. CICM ASM, Brisbane. 
  • Orford N, Vitamin D in critical illness, what’s the latest? 4th Nutrition in the Critically Ill Symposium, Melbourne. Mar 27, 2014
Grants
2017
  • Orford N. Effect of denosumab on bone turnover markers in critically ill women - A safety and feasibility, randomised, placebo, controlled trial. Malcolm Fisher Intensive Care Foundation Grant. $14,638

 

2014

  • Orford N. I-validate research program. Barwon Health Program Grant. $250,000
2013
  • Lambert N, Orford N. End-of-life communication for high-risk patients referred to ICU. Sydney Parker Fellowship, $75,000
  • Simpson N, Orford N. Implementation of a critical care tele-health program in South-Western Victoria. Victorian Govt Dept of Health. $250,000.
2012
  • Orford N. Changes in Bone Mineral Density in the Year after Critical Illness. Intensive Care Foundation Grant. $28,000.
2011
  • Orford N. Implementation and outcomes of a severe sepsis protocol in an Australian tertiary hospital. South-Western Victoria Program Grant. $40,000

 

Honours / Awards

PhD

  • Dr Matt Maiden
  • A/Prof Neil Orford

Masters